熊本大学大学院生命科学研究部 

2016年

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【総説】
・魏 范研、富澤一仁.tRNAのチオメチル化修飾による翻訳制御と代謝疾患。生化学 88 (3): 2016, 印刷中
【原著論文】

・Wu, Y., Wei, F.-Y., Kawarada, L., Suzuki, T., Araki, K., Fujimura, A., Kaitsuka, T., Oike, Y., Suzuki, T., and Tomizawa, K. Mtu1-mediated thiouridine formation of mitochondrial tRNAs is required for mitochondrial translation and is involved in the reversible infantile liver injury. PLos Genet. 12, e1006355, 2016.

・Watanabe, S., Wei, F.-Y., Matsunaga, T., Matsunaga, N., Kaistuka, T., Tomizawa, K. Oxytocin protects against stress-induced cell death in murine pancreatic beta-cells. Sci. Reports 6, 25185, 2016.

・Arimbasseri, A.G., Iben, J.R., Wei, F.-Y., Rijal, K., Tomizawa, K., Hafner, M., and Maraia, R.J. Evolving specificity of tRNA 3-methyl-cytidine-32 (m3C32) modification: a subset of tRNAsSer require isopentenylation of A37. RNA 22, 1400-1410, 2016.

・Lamichhane, T., Arimbasseri, A., Rijal, K., Iben, J.R., Wei, F.-Y., Tomizawa, K. and Maraia, R.J. Lack of tRNA-i6A37 modification causes mitochondrial-like metabolic deficiency in S. pombe by limiting activity of cytosolic tRNATyr, not mito-tRNA. RNA 22, 583-596, 2016.

・Wei, F.-Y., and Tomizawa, K. Measurement of 2-methylthio Modifications in Mitochondrial Transfer RNAs by Reverse-transcription Quantitative PCR. Bio-protocol 6(1), e1695, 2016.

・Hayashi, K., Michiue, H., Yamada, H., Takata, K., Nakayama, H., Wei, F.-Y., Fujimura, A., Tazawa, H., Asai, A., Ogo, N., Miyachi, H., Nishiki, T., Tomizawa, K., Takei, K., and Matsui, H. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci. Reports 6, 23372, 2016.

・Jamiruddin, M.R., Kaitsuka, T., Hakim, F., Fujimura, A., Wei, F.-Y., Saitoh, H., and Tomizawa, K. HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies. Biochem. Biophys. Res. Commun. 481, 25-30, 2016.

・Takeda, H., Kurioka, T., Kaitsuka, T., Tomizawa, K., Matsunobu, T., Hakim, F., Mizutari, K., Miwa, T., Yamada, T., Ise, M., Shiotani, A., Yumoto, E., and Minoda, R., Protein transduction therapy into cochleae via the round window niche in guinea pigs. Mol. Ther. Methods Clin Dev. 3, 16055, 2016.

・Chen, J., Kaitsuka, T., Fujino, R., Araki, K., Tomizawa, K., and Yamamoto, T. Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice. Neurosci. Lett. 629, 221-226, 2016.

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