熊本大学大学院生命科学研究部 

2005年

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【総説】
・ Wu, H.-Y., Matsui, H., and Tomizawa K. Crosstalk between calpain and calcineurin in excitotoxic neurodegeneration; Therapeutic targets for the treatment of excitotoxic neurodegeneration. Curr. Med. Chem.– Central Nervous System Agents 5: 207-216, 2005.
・ 吉野内光夫、金芬、松井秀樹、富澤一仁、平松祐司、山田健人、大和健嗣.HPVをターゲットとしたsiRNAの意義.産婦人科の世界 57:169-176, 2005.
・ 魏 范研、富澤一仁.プロテインキナーゼCdk5の神経機能に対する役割.生化学 77:436-439, 2005.

【原著論文】
・ Wei, F.-Y., Nagashima, K., Ohshima, T., Saheki, Y., Lu, Y.-F., Matsushita, M., Yamada, Y., Mikoshiba, K., Seino, Y., Matsui, H., and Tomizawa, K. Cdk5-dependent regulation of glucose-stimulated insulin secretion. Nat. Med. 11: 1104-1108, 2005.
・ Liu, F., Grundke-Iqbal, I., Iqbal, K., Oda, Y., Tomizawa, K., Gong C.-X. Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. J. Biol. Chem. 280: 37755-37762, 2005.
・ Ohshima, T., Ogura, H., Tomizawa, K., Hayashi, K., Suzuki, H., Saito, T., Kamei, H., Nishi, A., Bibb, J. A., Hisanaga, S., Matsui, H., and Mikoshiba K. Impairment of hippocampal long-term depression and defective spatial learning and memory in p35-/- Mice. J. Neurochem. 94: 917-925, 2005.
・ Wu, H.-Y., Yuen E.Y., Lu, Y.-F., Matsushita, M., Matsui, H., Yan, Z., and Tomizawa, K. Regulation of NMDA receptors by calpain in cortical neurons. J. Biol. Chem. 280: 21588-21593, 2005.
・ Matsushita, M., Kozak, J.A., Shimizu, Y., McLachlin, D.T., Yamaguchi, H., Wei, F.Y., Tomizawa, K., Matsui, H., Chait, B.T., Cahalan, M.D., and Nairn, A.C. Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/CHAK1. J. Biol. Chem. 280: 20793-20803, 2005.
・ Wei, F.-Y., Tomizawa, K., Ohshima, T., Asada, A., Saito, T., Nguyen C., Bibb, J.A., Ishiguro, K., Kulkarni, A.B., Pant, H.C., Mikoshiba, K., Matsui, H., and Hisanaga, S. Control of Cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability. J. Neurochem. 93: 502-512, 2005.
・ Saheki, Y, Li, S.-T., Matsushita, M., Wu, Y.-M., Cai, W.-H., Wei, F.-Y., Lu, Y.-F., Moriwaki, A., Tomizawa, K., and Matsui, H. A new approach to inhibiting astrocytic IP3-induced intracellular calcium increase in an astrocyte-neuron co-culture system. Brain Res. 1055: 196-201, 2005.
・ Michiue, H., Tomizawa, K., Matsushita, M., Tamiya, T., Lu, Y.-F., Ichikawa, T., Date, I., and Matsui, H. Ubiquitination-resistant p53 protein transduction therapy facilitates anti-cancer effect on the growth of human malignant glioma cells. FEBS Lett. 579: 3965-3969, 2005.
・ Kumashiro, S., Lu, Y.-F., Tomizawa, K., Matsushita, M., Wei, F.-Y., and Matsui, H. Regulation of synaptic vesicle recycling by calcineurin in different vesicle pools. Neurosci. Res. 51: 435-443, 2005.
・ Michiue, H., Tomizawa, K., Wei, F.-Y., Matsushita, M., Lu, Y.-F., Ichikawa, T., Tamiya, T., Date, I., and Matsui, H. The NH-2-terminal of influenza virus hemagglutinin-2 subunit peptides enhance the anti-tumor potency of poly-arginine-mediated p53 protein transduction. J. Biol. Chem. 280: 8285-8289, 2005.
・ Arataki, S., Tomizawa, K., Moriwaki, A., Nishida, K., Matsushita, M., Ozaki, T., Kunisada, T., Yoshida, A., Inoue, H., and Matsui, H. Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats. J. Neurotrauma 22: 398-406, 2005.
・ Ito S., Murakami A., Sato K., Nishina Y., Shiga K., Takahashi T., Higashi S., Iseki M., & Watanabe M. Photocycle features of heterologously expressed and assembled eukaryotic flavin-binding BLUF domains of photoactivated adenylyl cyclase (PAC), a blue-light receptor in Euglena gracilis. Photochemical & Photobiological Sciences. 4(9), 762–769, 2005

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